Genetic landscape of indolent and aggressive Kaposi sarcomas.

ABSTRACT:

Background

Kaposi sarcoma (KS) is a rare skin tumour caused by herpesvirus 8 infection and characterized by either indolence or an aggressive course necessitating systemic therapies. The genetic basis of this difference remains unknown.

Objectives

To explore the tumour mutational burden in indolent and aggressive KS.

Methods

We performed whole-exome sequencing on a cohort of 21 KS patients. We compared genetic landscape including tumor mutational burden between the two forms of indolent and agressive KS.

Results

Aggressive KS tumours had a significantly higher TMB and a larger cumulative number of deleterious mutations than indolent KS tumours. In addition, all aggressive tumours had at least three deleterious mutations, whereas most indolent tumours harboured

SUBMITTER: Malouf GG 

PROVIDER: S-EPMC11803637 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature