Post-Myocardial Infarction Remodeling and Hyperkinetic Remote Myocardium in Sheep Measured by Cardiac MRI Feature Tracking.

ABSTRACT:

Background

Cardiac MRI feature tracking (FT) allows objective assessment of segmental left ventricular (LV) function following a myocardial infarction (MI), but its utilization in sheep, where interventions can be tested, is lacking.

Purpose

To apply and validate FT in a sheep model of MI and describe post-MI LV remodeling.

Study type

Animal model, longitudinal.

Animal model

Eighteen lambs (6 months, male, n = 14; female, n = 4; 25.2 ± 4.5 kg).

Field strength/sequence

Two-dimensional balanced steady-state free precession (bSSFP) and 3D inversion recovery fast low angle shot (IR-FLASH) sequences at 3 T.

Assessment

Seven lambs underwent test-retest imaging to assess FT interstudy reproducibility. MI was induced in the remaining 11 by coronary ligati

SUBMITTER: Cho SKS 

PROVIDER: S-EPMC11803690 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature