Effects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes.

ABSTRACT: We performed all-atom and coarse-grained simulations of lipid bilayer mixtures of the unsaturated lipid DOPC, with saturated lipids having the same 18-carbon acyl tails and different headgroups, to understand their mechanical properties. The secondary lipids were DSPG, DSPA, DSPS, DSPC, and DSPE. The DOPC:DSPG system with 65:35 molar ratio was the softest, with area compressibility modulus K_A ∼ 22% smaller than the pure DOPC value. Raising the mole % of DOPC leads to increases in K_A, yet at any given composition the K_A trend is DSPG < DSPA < DSPS < DSPC < DSPE. Lipid-lipid interactions are weaker in DOPC:DSPG mixtures and stronger in DSPE systems. The head and phosphate groups of the secondary lipids DSPG, DSPA, and

SUBMITTER: Xu J 

PROVIDER: S-EPMC11803717 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature