Palladium-Catalyzed Oxidative Allene-Allene Cross-Coupling.

ABSTRACT: Direct cross-coupling reactions between two similar unactivated partners are challenging but constitute a powerful strategy for the creation of new carbon-carbon bonds in organic synthesis. [4]Dendralenes are a class of acyclic branched conjugated oligoenes with great synthetic potential for the rapid generation of structural complexity, yet the chemistry of [4]dendralenes remains an unexplored field due to their limited accessibility. Herein, we report a highly selective palladium-catalyzed oxidative cross-coupling of two allenes with the presence of a directing olefin in one of the allenes, enabling the facile synthesis of a broad range of functionalized [4]dendralenes in a convergent modular manner. Specifically, the selective allenic C-H activation of an allene with an allyl substituen

SUBMITTER: Wu H 

PROVIDER: S-EPMC11803718 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature