Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation.

ABSTRACT:

Objective

To investigate the role of microvascular pericyte dysfunction in antibody-mediated rejection (ABMR) of transplanted kidneys.

Methods

A total of 160 patients who underwent kidney transplantation in our hospital from 2004 to 2020 were enrolled, divided into 4 groups: ABMR group (n = 79), TCMR group (n = 20), mixed rejection group (n = 25) and control group (n = 36). Postoperative renal function indicators were compared, and immunohistochemical and immunofluorescence staining was performed on graft tissues and mice models using the pericyte marker PDGFR-β. An in vitro pericyte dysfunction model was co-cultured with vascular endothelial cells for functional assessment through Western blotting, PCR, and wound healing tests. KEGG pathwa

SUBMITTER: Xu J 

PROVIDER: S-EPMC11803764 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature