Efficacy of Mineralocorticoid Receptor Antagonists on Kidney and Cardiovascular Outcomes in Patients With Chronic Kidney Disease: An Umbrella Review.

ABSTRACT:

Rationale & objective

To comprehensively summarize the efficacy of mineralocorticoid receptor antagonists (MRAs) to improve kidney and cardiovascular (CV) outcomes in patients with chronic kidney disease (CKD).

Study design

Relevant studies were identified from Medline and Scopus databases from their inception up to August 2023.

Setting & study populations

Patients with nondialysis or dialysis CKD.

Selection criteria for studies

Systematic reviews and meta-analyses (SR-MAs) of randomized controlled trials (RCTs) that investigated the efficacy of MRAs on kidney and CV outcomes in patients with nondialysis or dialysis CKD were included in this study.

Data extraction

Characteristics of studies and participants, and treatment effects were extracted.

Analy

SUBMITTER: Amornritvanich P 

PROVIDER: S-EPMC11803877 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature