CD47 is a tumor cell-derived exosomal signature and regulates tumor immune microenvironment and immunotherapy responses.

ABSTRACT:

Background

The pathogenesis of ovarian cancer (OvCa) involves a complex interplay of genetic, environmental, and hormonal factors. With the in-depth exploration of tumor ecosystem, exosomes can mediate the immunological status of tumor microenvironment (TME). Therefore, we aimed to recognize the tumor-derived exosomes (TEXs) which can distinguish the immune-hot and cold tumors and reflect the immunotherapeutic responses.

Methods

A large set of transcriptomic and single-cell RNA-sequencing (scRNA-seq) datasets were downloaded and used to analyze the expression pattern of CD47 and its immuno-correlations in OvCa and multiple epithelial cell carcinomas such as breast cancers. In addition, a pan-gynecological cancer cohort was used to validate the correlation between CD47 and th

SUBMITTER: Luan Y 

PROVIDER: S-EPMC11803903 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature