Causal role of plasma liposome in diabetic retinopathy: mendelian randomization (MR) study.

ABSTRACT:

Background

Research indicates that there may be an association between plasma lipidome levels and the incidence of diabetic retinopathy (DR) in patients. However, the potential causality of this relationship is yet to be determined. To investigate this matter further, we employed a two-sample Mendelian randomization (MR) analysis to comprehensively assess the causality between lipidome levels and DR.

Methods

Summary statistics for lipid levels and DR were obtained from the Genome-Wide Association Studies (GWAS) Catalog database and the FinnGen Consortium, respectively. We conducted a two-sample MR analysis, and statistical analysis were performed using the inverse variance weighted (IVW) with the addition of the MR-Egger, weighted median (WM), constrained maximum likelihood

SUBMITTER: Yin K 

PROVIDER: S-EPMC11803952 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature