Enhanced brightness and photostability of dye-sensitized Nd-doped rare earth nanocomposite for in vivo NIR-IIb vascular and orthotopic tumor imaging.

ABSTRACT: Rare-earth doped nanoparticles (RENPs) have shown promise in biomedical imaging, particularly within the NIR-IIb region, due to their deep tissue penetration and minimal light scattering. However, challenges such as low extinction coefficients, narrow excitation spectra, and prone to quenching in aqueous environments limit their effectiveness. To overcome these obstacles, we developed a novel dye-sensitized, onion-like Nd-doped RENP nanocomposite to enhance NIR-IIb imaging performance. The onion-like Nd-RENP nanocomposite markedly enhances emission intensity at 1525 nm within the NIR-IIb range by reducing quenching and improving spectral overlap. The integration of an IR783-containing micellar layer further stabilizes the NIR dye, mitigating quenching and photobleaching. In vivo imaging st

SUBMITTER: Lin SL 

PROVIDER: S-EPMC11803961 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature