Modulating the developing gut microbiota with 2'-fucosyllactose and pooled human milk oligosaccharides.

ABSTRACT:

Background

Synthetic human milk oligosaccharides (HMOs) are used to supplement infant formula despite limited understanding of their impact on the post-weaned developing gut microbiota. Here, we assess the influence of 0.5 g/L 2-fucosyllactose (2'FL) and 4.0 g/L pooled HMOs (pHMOs) on the composition and activity of cultured fecal-derived microbial communities from seven healthy young children.

Results

Exposure to pHMOs induced significant shifts in both the microbial community composition and metabolic output, including an increased abundance of several genera, notably Bacteroides, and the production of health-associated metabolites. In contrast, 2'FL alone did not lead to substantial changes in the communities. A total of 330 bacterial isolates, spanning 157 species, were

SUBMITTER: Renwick S 

PROVIDER: S-EPMC11803978 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature