Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration.

ABSTRACT:

Background

Dysregulation of maternal glucose homeostasis has been related to an increased risk of morbidity and mortality in mothers and fetuses, yet the mechanism remains unclear. This study investigated the association between maternal glycemic levels and placental epigenetic age acceleration (PAA) in a multiethnic cohort.

Methods

In a sample of 301 pregnant women (102 Hispanic, 77 White, 72 Black, and 50 Asian/Pacific Islander), the association of glycemic markers cumulative exposure with PAA was tested using linear regression adjusting for fetal sex, maternal age, educational status, and health insurance status. Models were applied in the full cohort and stratified by race/ethnicity. Further, sensitivity analyses were performed after excluding women with GDM or preeclamp

SUBMITTER: Habtewold TD 

PROVIDER: S-EPMC11803985 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature