Antibiotic-associated changes in Akkermansia muciniphila alter its effects on host metabolic health.

ABSTRACT:

Background

Altered gut microbiota has emerged as a major contributing factor to the etiology of chronic conditions in humans. Antibiotic exposure, historically dating back to the mass production of penicillin in the early 1940s, has been proposed as a primary contributor to the cumulative alteration of microbiota over generations. However, the mechanistic link between the antibiotics-altered microbiota and chronic conditions remains unclear.

Results

In this study, we discovered that variants of the key beneficial gut microbe, Akkermansia muciniphila, were selected upon exposure to penicillin. These variants had mutations in the promoter of a TEM-type β-lactamase gene or pur genes encoding the de novo purine biosynthesis pathway, and they exhibited compromised abilities to mi

SUBMITTER: Han Y 

PROVIDER: S-EPMC11804010 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature