A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer.

ABSTRACT:

Purpose

An earlier multicenter phase III study demonstrated the safety and efficacy of mitoxantrone hydrochloride injection for tracing (MHI) for detecting sentinel lymph nodes (SLNs) in breast cancer patients. This ancillary study was conducted to further analyze and discover differences between the two tracers that had not been reported previously.

Methods

This analysis used single-center data from a phase III trial. Patients with breast cancer were injected with both MHI and 99mTc as SLN tracers before surgery. To account for cluster effects of multiple SLNs from the same patient and further analyze the differences between the two methods and factors that could impact detection, Obuchowski's modified McNemar test, the GLIMMIX model, and univariate and multivariate analyse

SUBMITTER: Jiao D 

PROVIDER: S-EPMC11804033 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature