The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver diseases characterized by hepatic steatosis exceeding 5% in the absence of alcohol and other liver-damaging factors. Clinical studies have identified a potential link between abnormal iron metabolism and the high incidence of NAFLD; however, the results from clinical trials remain inconsistent. This meta-analysis aims to compare serum hepcidin levels and the hepcidin/ferritin ratio between adults with NAFLD and those without to explore their potential relationship with NAFLD.

Methods

A systematic search was conducted across the Web of Science platform, Cochrane, Scopus, Embase, and PubMed databases from their inception until December 18, 2024. The analysis primarily focused on serum hepcidin

SUBMITTER: Song J 

PROVIDER: S-EPMC11804044 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature