The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies have shown an association between cerebrospinal fluid (CSF) metabolites and low back pain (LBP), but the causal relationship between these factors remains unclear.

Methods

We performed a two-sample Mendelian randomization (MR) analysis to examine whether there is a causal relationship between CSF metabolites and LBP. We applied several MR methods, including inverse variance weighting, weighted median, MR-Egger, Wald ratio, and MR-PRESSO, to test the causal relationship and conducted a sensitivity analysis to assess the robustness of the results.

Results

We identified a total of 12 CSF metabolites significantly associated with LBP, of which Bilirubin, 5,6-dihydrothymine, Erythronate, Mannitol/sorbitol, and Butyrate have a potential inhi

SUBMITTER: Peng R 

PROVIDER: S-EPMC11804052 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature