Circulating microRNA panels for multi-cancer detection and gastric cancer screening: leveraging a network biology approach.

ABSTRACT:

Background

Screening tests, particularly liquid biopsy with circulating miRNAs, hold significant potential for non-invasive cancer detection before symptoms manifest.

Methods

This study aimed to identify biomarkers with high sensitivity and specificity for multiple and specific cancer screening. 972 Serum miRNA profiles were compared across thirteen cancer types and healthy individuals using weighted miRNA co-expression network analysis. To prioritize miRNAs, module membership measure and miRNA trait significance were employed. Subsequently, for specific cancer screening, gastric cancer was focused on, using a similar strategy and a further step of preservation analysis. Machine learning techniques were then applied to evaluate two distinct miRNA panels: one for multi-cancer

SUBMITTER: Kamkar L 

PROVIDER: S-EPMC11804061 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature