Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility.

ABSTRACT:

Background

Associations of anxiety disorder and depression with coronary artery disease (CAD) are heterogeneous between populations. This study investigated how genetic susceptibility to CAD alters these associations with incident CAD, comparing and combining anxiety disorder and depression.

Methods

This is a prospective cohort study using UK Biobank. Diagnoses of anxiety disorder and depression were ascertained through linked hospital admission data. Incident CAD was ascertained through hospital admission and death certificate data after baseline. CAD polygenic risk score (PRS_CAD) was obtained from CARDIoGRAMplus4 and categorised into low, intermediate, and high. Cox proportional hazard models were used to examine associations between anxiety disorder and depress

SUBMITTER: Nakada S 

PROVIDER: S-EPMC11804096 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature