Genetic Markers of Postmortem Brain Iron.

ABSTRACT: Brain iron (Fe) dyshomeostasis is implicated in neurodegenerative diseases. Genome-wide association studies (GWAS) have identified plausible loci correlated with peripheral levels of Fe. Systemic organs and the brain share several Fe regulatory proteins but there likely exist different homeostatic pathways. We performed the first GWAS of inductively coupled plasma mass spectrometry measures of postmortem brain Fe from 635 Rush Memory and Aging Project (MAP) participants. Sixteen single nucleotide polymorphisms (SNPs) associated with Fe in at least one of four brain regions were measured (p < 5 × 10^-8). Promising SNPs (p < 5 × 10^-6) were followed up for replication in published GWAS of blood, spleen, and brain imaging Fe traits and mapped to candidate genes for targete

SUBMITTER: Cornelis MC 

PROVIDER: S-EPMC11804167 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature