Vimentin modulates regulatory T cell receptor-ligand interactions at distal pole complex, leading to dysregulated host response to viral pneumonia.

ABSTRACT: Forkhead box P3 (Foxp3)⁺ regulatory T cells (Tregs) resolve acute inflammation and repair the injured lung after viral pneumonia. Vimentin is a critical protein in the distal pole complex (DPC) of Tregs. This study reveals the inhibitory effect of vimentin on the suppressive and reparative capacity of Tregs. Treg-specific deletion of vimentin increases Helios⁺interleukin-18 receptor (IL-18R)⁺ Tregs, suppresses inflammatory immune cells, and enhances tissue repair, protecting Vim^fl/flFoxp3^YFP-cre mice from influenza-induced lung injury and mortality. Mechanistically, vimentin suppresses the induction of amphiregulin, an epidermal growth factor receptor (EGFR) ligand necessary for tissue repair, by sequestering IL-18R to the DPC and rest

SUBMITTER: Ma R 

PROVIDER: S-EPMC11804169 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature