Spontaneous Abortion and Myocardial Infarction: A Mendelian Randomization Investigation and Transcriptomic Analysis.

ABSTRACT:

Background

A link has been found between spontaneous abortion (SA) and myocardial infarction (MI). However, there is still a lack of comprehensive knowledge regarding the genetic links and biological mechanisms between SA and MI. An investigation of the causal association between SA and MI, along with the associated signaling networks, was conducted using univariate Mendelian randomization (MR) and transcriptome analysis.

Methods

Data from genome-wide association studies (GWAS) for SA and MI were analyzed using the FinnGen consortium database. To assess the causality between SA and MI, various methods were employed including inverse-variance-weighted (IVW), weighted median, simple mode, and weighted mode analyses. Sensitivity analysis was conducted using heterogeneity, pleio

SUBMITTER: Xiang S 

PROVIDER: S-EPMC11804178 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature