Revascularization in frail patients with acute coronary syndromes: a retrospective longitudinal study.

ABSTRACT:

Background and aims

Frailty is increasingly prevalent in people presenting with acute coronary syndrome (ACS). This high-risk group is typically excluded from trials of interventions in ACS, and there is uncertainty about the risks and benefits of invasive management.

Methods

Patients with an ACS diagnosis between 2010 and 2015 in England were identified from Hospital Episode Statistics, with linked Office for National Statistics mortality data. Frailty was defined by the Hospital Frailty Risk Score. Causal inference analysis used regional variation in revascularization as an instrumental variable to estimate average treatment effects of revascularization on cardiovascular mortality up to 5 years in people presenting with ACS and low-, intermediate-, or high-risk frailty.

SUBMITTER: Roman M 

PROVIDER: S-EPMC11804245 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature