Sex-related differences in the clinical course of aortic root and ascending aortic aneurysms: the DisSEXion Study.

ABSTRACT:

Background and aims

To explore male-female differences in aneurysm growth and clinical outcomes in a two-centre retrospective Dutch cohort study of adult patients with ascending aortic aneurysm (AscAA).

Methods

Adult patients in whom imaging of an AscAA (root and/or ascending: ≥40 mm) was performed between 2007 and 2022 were included. Aneurysm growth was analysed using repeated measurements at the sinuses of Valsalva (SoV) and tubular ascending aorta. Male-female differences were explored in presentation, aneurysm characteristics, treatment strategy, survival, and clinical outcomes.

Results

One thousand eight hundred and fifty-eight patients were included (31.6% female). Median age at diagnosis was 65.4 years (interquartile range: 53.4-71.7) for females and 59.0 years

SUBMITTER: Notenboom ML 

PROVIDER: S-EPMC11804247 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature