Mutational profiling of lung adenocarcinoma in China detected by next-generation sequencing.

ABSTRACT:

Purpose

NSCLC is the most common type of lung cancers. The purpose of this study is to screen cancer-related mutations in early LUAD in China through NGS technology, determine their correlation with clinical characteristics and provide basis for treatment decisions.

Methods

In this study, we performed a 583 gene panel to detect the mutational spectrum of the tumors which were collected from 98 LUAD patients. The sequencing data and clinical characteristics were analyzed.

Results

Mutations were identified in 94.9% of patients. EGFR had the highest mutation frequency which was detected in 66% of the patients and was significantly associated with female gender and non-smoking history. Other genes with high mutation frequency were TP53 (37%), ERBB2 (24%), BCOR (22%), ZFHX

SUBMITTER: Zhou X 

PROVIDER: S-EPMC11804368 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature