Optimal strategies for correcting merotelic chromosome attachments in anaphase.

ABSTRACT: Accurate chromosome segregation in mitosis depends on proper connections of sister chromatids, through microtubules, to the opposite poles of the early mitotic spindle. Transiently, many inaccurate connections are formed and rapidly corrected throughout the mitotic stages, but a small number of merotelic connections, in which a chromatid is connected to both spindle poles, remain lagging at the spindle's equator in anaphase. Most of the lagging chromatids are eventually moved to one or the other pole, likely by a combination of microtubules' turnover and the brute force of pulling by the microtubules' majority from the one pole against the microtubules' minority from the other pole. We use computer simulations from two stochastic models (1D and full 3D CellDynaMo model) combining force bal

SUBMITTER: Kliuchnikov E 

PROVIDER: S-EPMC11804472 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature