Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis.

ABSTRACT:

Purpose

This systematic review and meta-analysis aimed to assess the changes in retinal layer thickness and vascular density in patients diagnosed with keratoconus (KC).

Methods

We conducted a thorough search in PubMed, Scopus, Embase, and Web of Science, encompassing all observational studies from January 1990 to February 2024. We analyzed the data using STATA software 17 and the random effects model with the restricted maximum likelihood (REML) or maximum likelihood (ML) method to pool the standardized mean difference (SMD) and the weighted mean difference (WMD) of retinal thickness and vascular density compared to non-KC eyes.

Results

From 4608 records, 16 primary studies met our inclusion criteria, involving 1932 eyes in two groups. The meta-analysis revealed a si

SUBMITTER: Vahedi H 

PROVIDER: S-EPMC11804566 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature