RS, S (+) - and R (-)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies.

ABSTRACT: In this paper, cocrystal polymorphs of RS-ibuprofen (RS-IBU), S (+)-ibuprofen (S(+)-IBU), R (-)-ibuprofen (R(-)-IBU) with nicotinamide (NIC) were synthesized by different methods. RS-IBU is a chiral drug with only one chiral center in the molecule, which has two enantiomers (S (+)-IBU and R (-)-IBU). Due to the low solubility and bioavailability of IBU, its application is limited. The pharmaceutical cocrystal technology can improve the physicochemical properties of the drug. In this paper, we characterized RS-IBU, S (+)-IBU, R (-)-IBU, NIC, physical mixtures and cocrystal polymorphs by terahertz (THz), Raman and X-ray Diffraction (XRD), respectively. By observing the experimental results, we could clearly distinguish the cocrystal polymorphs. We found that the melt recrystallization method

SUBMITTER: Jing Y 

PROVIDER: S-EPMC11804694 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature