Random antimicrobial peptide mixtures as non-antibiotic antimicrobial agents for cultured meat industry.

ABSTRACT: Antibiotics, commonly used in cell culture studies to prevent microbial contamination, cannot be employed in Cultured meat (CM) due to potential residues in the final food products. Hence, there is an urgent need to develop novel and safe non-antibiotic antimicrobial agents. Here, we investigated the potential of random antimicrobial peptide mixtures (RPMs) as non-antibiotic antimicrobial agents. RPMs are synthetic peptide cocktails that have previously shown strong and broad antimicrobial activity; however, their use in cell culture media and their effect on mammalian cells have not yet been explored. Here we show that RPMs had no significant impact on mesenchymal stem cells (MSCs) at concentrations that effectively inhibit bacterial growth. RPMs displayed strong bactericidal activity aga

SUBMITTER: Yakir I 

PROVIDER: S-EPMC11804736 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature