Critical assessment of knowledge-based models for craniospinal irradiation of paediatric patients.

ABSTRACT:

Background and purpose

Knowledge-Based Planning (KBP) is increasingly used to standardize and optimize radiotherapy planning. This study aims to develop, refine, and compare multicentric KBP models for craniospinal irradiation (CSI) in pediatric patients.

Materials and methods

A total of 113 CSI treatments from three Italian centers were collected, comprising Computed Tomography scans, target and organ contours, and treatment plans. Treatment techniques included Helical Tomotherapy (HT) and Volumetric Modulated Arc Therapy (VMAT). Three KBP models were developed: a full model (F-model) using data from 87 patients, a reduced model (R-model) based on a subset of the same sample, and a replanned model (RP-model) using KBP re-optimized plans. Models' quality was evaluated using

SUBMITTER: Caricato P 

PROVIDER: S-EPMC11804776 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature