Development of a tri-species wound model for studying fungal-bacterial interactions and antimicrobial therapies.

ABSTRACT: Chronic wounds are increasing in numbers and biofilm-producing bacteria are highly prevalent in these wounds and often create resilient polymicrobial infections. Moreover, estimates suggest that up to 23 % of wounds contain fungi, particularly Candida albicans. Currently, inter-kingdom chronic wound models are scarce; thus, this study presents one of the few in vitro models that incorporate both bacterial and fungal species in a wound-relevant environment, addressing a critical gap in current biofilm research. The newly developed model contained the commonly isolated wound bacteria Pseudomonas aeruginosa and Staphylococcus aureus, and the fungus Candida albicans. Inter-species interactions were investigated through selective plate counting and pH and oxyg

SUBMITTER: Sorensen S 

PROVIDER: S-EPMC11804781 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature