Repeated and alternate stimulations with dsRNA and SEB alter responses in macrophages and epithelial cells.

ABSTRACT:

Introduction

The innate immune system is activated by foreign molecules via pattern recognition receptors and other surveillance systems, producing diverse cytokines that recruit and activate other immune cells. Recent studies have shown that once activated by foreign molecules, the innate immune system exhibits altered responses upon subsequent exposure to the same or different infectious agents, such as lipopolysaccharides (LPS) or bacteria. However, as these alterations in response to viral infection and staphylococcal enterotoxin B (SEB) in the airways have not been fully elucidated, we focused on the changes in immune responses induced by repeated stimulation of macrophages and epithelial cells with foreign molecules.

Methods

THP-1-derived macrophages and BEAS-2B epithe

SUBMITTER: Choi JP 

PROVIDER: S-EPMC11804812 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature