Therapeutic strategies for fungating and ulcerating breast cancers: A systematic review and narrative synthesis.

ABSTRACT:

Background

To identify optimal therapeutic strategies for managing fungating, large or ulcerating breast tumors and highlight existing gaps in the literature.

Methods

We conducted a systematic search of Medline, Embase, APA, PsycInfo, CAB abstracts, Scopus, and Web of Science from inception to June 30, 2024, including studies on patients with fungating, large, or ulcerating breast cancers.

Results

The search identified 7917 studies, with 79 meeting the inclusion criteria: 62 case reports, 7 case series, and 10 cohort studies. Owing to high heterogeneity, a narrative synthesis was performed, categorizing treatment by year, molecular subtype, histology, and staging. We found that treatment modalities increased, from an average of two in luminal-B cancers to three in HER

SUBMITTER: Zagardo V 

PROVIDER: S-EPMC11804823 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature