Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock.

ABSTRACT: Cardiogenic shock (CS) is a medical emergency with high in-hospital mortality. New biomarkers are needed to identify patients at a greater risk of adverse outcomes. This study aimed to investigate the prognostic potential of microRNAs (miRNAs) in assessment of the outcome of cardiogenic shock. Circulating miRNA levels were measured by quantitative PCR in plasma samples collected at baseline from 165 patients of the multicenter, prospective, observational CardShock study and compared between in-hospital and 90-day survivors and non-survivors. Of the 10 studied miRNAs, median levels of miR-20b-5p at baseline were significantly higher in in-hospital and 90-day survivors compared to non-survivors [median 0.014 arbitrary units (AU) (interquartile range (IQR) 0.003-0.024) vs. 0.008 AU (IQ

SUBMITTER: Mantyla T 

PROVIDER: S-EPMC11804825 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature