Homogenization of word relationships in schizophrenia: Topological analysis of cortical semantic representations.

ABSTRACT:

Aim

Patients with schizophrenia typically exhibit symptoms of disorganized thought and display concreteness and over-inclusion in verbal reports, depending on the level of abstraction. While concreteness and over-inclusion may appear contradictory, the underlying psychopathology that explains these symptoms remains unclear. In the current study, we used functional magnetic resonance imaging with an encoding modeling approach to examine how concepts of various words, represented as brain activity, are anomalously connected at different levels of abstraction in patients with schizophrenia.

Methods

Fourteen individuals diagnosed with schizophrenia and 17 healthy controls underwent functional magnetic resonance imaging to measure brain activity representing concepts of various w

SUBMITTER: Hayashi R 

PROVIDER: S-EPMC11804922 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature