Exposome-wide association study of cognition among older adults in the National Health and Nutrition Examination Survey.

ABSTRACT: Cognitive impairment among older adults is a growing public health challenge and environmental chemicals may be modifiable risk factors. A wide array of chemicals has not yet been tested for association with cognition in an environment-wide association framework. In the US National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2011-2014 cross-sectional cycles, cognition was assessed using the Digit Symbol Substitution Test (DSST, scores 0-117) among participants aged 60 years and older. Concentrations of environmental chemicals measured in blood or urine were log₂ transformed and standardized. Chemicals with at least 50% of measures above the lower limit of detection were included (n_chemicals = 147, n_classes=14). We tested for associations

SUBMITTER: Middleton LYM 

PROVIDER: S-EPMC11805339 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature