Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development.

ABSTRACT: Infection by the liver fluke, Fasciola hepatica, places a substantial burden on the global agri-food industry and poses a significant threat to human health in endemic regions. Widespread resistance to a limited arsenal of chemotherapeutics, including the frontline flukicide triclabendazole (TCBZ), renders F. hepatica control unsustainable and accentuates the need for novel therapeutic target discovery. A key facet of F. hepatica biology is a population of specialised stem cells which drive growth and development - their dysregulation is hypothesised to represent an appealing avenue for control. The exploitation of this system as a therapeutic target is impeded by a lack of understanding of the molecular mechanisms underpinning F. hepatica growth and development. Wnt signalling pathways go

SUBMITTER: Armstrong R 

PROVIDER: S-EPMC11805424 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature