Challenging a paradigm: Staggered versus single-pulse mass dog vaccination strategy for rabies elimination.

ABSTRACT:

Background

From smallpox to poliomyelitis, halting contagion transmission through simultaneous mass vaccination is ubiquitous and often perceived as the only possible solution. But implementing mass vaccination campaigns in large populations within a short period poses many challenges. For example, in Arequipa, Peru, sweeping mass vaccination campaigns conducted yearly over a single weekend have failed to achieve the required 'herd immunity' to halt canine rabies transmission. Contrary to the global paradigm of a simultaneous campaign, the 2022 Arequipa rabies campaign was implemented at the sub-district level (patches), with dates of the campaign staggered across 6 months.

Methods

We constructed a stochastic, metapopulation model to examine how the timing of pulsed vaccinat

SUBMITTER: Bellotti BR 

PROVIDER: S-EPMC11805426 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature