Fitting and comparison of calcium-calmodulin kinetic schemes to a common data set using non-linear mixed effects modelling.

ABSTRACT: Calmodulin is a calcium binding protein that is essential in calcium signalling in the brain. There are many computational models of calcium-calmodulin binding that capture various calmodulin features. However, existing models have generally been fit to different data sets, with some publications not reporting their training and validation performance. Moreover, there is no model comparison using a common benchmark data set as is common practice in other modeling domains. Finally, some calmodulin models have been fit as a part of a larger kinetic scheme, which may have resulted in parameters being underdetermined. We address these three limitations of previous models by fitting the published calcium-calmodulin schemes to a common calcium-calmodulin data set comprising equilibrium data from

SUBMITTER: Linkevicius D 

PROVIDER: S-EPMC11805441 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature