Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant <i>Salmonella</i>.

ABSTRACT: Discovering new strategies to combat the multidrug-resistant bacteria constitutes a major medical challenge of our time. Previously, artesunate (AS) has been reported to exert antibacterial enhancement activity in combination with β-lactam antibiotics via inhibition of the efflux pump AcrB. However, combination of AS and colistin (COL) revealed a weak synergistic effect against a limited number of strains, and few studies have further explored its possible mechanism of synergistic action. In this article, we found that AS and EDTA could strikingly enhance the antibacterial effects of COL against mcr-1^- and mcr-1⁺ Salmonella strains either in vitro or in vivo, when used in triple combination. The excellent bacteriostatic effect was primarily relate

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC11805504 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature