Unusual Presentation of a Rare Case of Immunotherapy Combination-Induced Encephalitis: A Case Report.

ABSTRACT:

Introduction

Immune checkpoint inhibitors have revolutionized cancer treatment owing to their ability to activate cellular immune checkpoint pathways and mediate an antitumor activity. Due to their immunological actions, immune-related adverse events (irAEs) have become a concern. Neurological adverse events are rarely seen whether in the central or peripheral nervous system and can be potentially life-threatening. We present a rare case of occipital encephalitis following dual immunotherapy treatment in a patient with melanoma.

Case presentation

A 41-year-old man diagnosed with nodular melanoma of the right torso with axillary lymphadenopathies was treated with dual immunotherapy: nivolumab and ipilimumab. After 24 weeks, patient developed right homolateral hemianopia, and

SUBMITTER: Sfeir P 

PROVIDER: S-EPMC11805547 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature