2-[¹⁸F]Fluoropropionic Acid PET Imaging of Doxorubicin-Induced Cardiotoxicity.

ABSTRACT:

Purpose

Treatment of pediatric cancers with doxorubicin is a common and predictable cause of cardiomyopathy. Early diagnosis of treatment-induced cardiotoxicity and intervention are major determinants for the prevention of advanced disease. The onset of cardiomyopathies is often accompanied by profound changes in lipid metabolism, including an enhanced uptake of short-chain fatty acids (SCFA). Therefore, we explored the utility of 2-[¹⁸F]fluoropropionic acid ([¹⁸F]FPA), an SCFA analog, as an imaging biomarker of cardiac injury in mice exposed to doxorubicin.

Procedures

Cardiotoxicity and cardiac dysfunction were induced in mice by an 8-dose regimen of doxorubicin (cumulative dose 24 mg/kg) administered over 14 days. The effects of doxorubicin exposure w

SUBMITTER: Azcona JA 

PROVIDER: S-EPMC11805620 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature