CERS1 is a biomarker of Staphylococcus aureus abundance and atopic dermatitis severity.

ABSTRACT:

Background

Atopic dermatitis (AD) is an inflammatory skin condition characterized by widely variable cutaneous Staphylococcus aureus abundance that contributes to disease severity and rapidly responds to type 2 immune blockade (ie, dupilumab). The molecular mechanisms regulating S aureus levels between AD subjects remain poorly understood.

Objective

We investigated host genes that may be predictive of S aureus abundance and correspond with AD severity.

Methods

We studied data derived from the National Institutes of Health/National Institute of Allergy and Infectious Diseases-funded (NCT03389893 [ADRN-09]) randomized, double-blind, placebo-controlled multicenter study of dupilumab in adults (n = 71 subjects) with moderate-to-severe AD. Bulk RNA sequencing of skin biops

SUBMITTER: Kenney HM 

PROVIDER: S-EPMC11805642 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature