Prehabilitation to improve function after autologous stem cell transplantation: A pilot randomized controlled trial (PIRATE).

ABSTRACT:

Purpose

Exercise and nutrition interventions are not part of routine care for those undergoing autologous stem cell transplant (autoSCT). We aimed to explore estimates of effect, safety and feasibility of multidisciplinary prehabilitation for improving physical capacity after autoSCT.

Methods

This single-blinded, parallel, two-armed pilot randomized trial included adults receiving autoSCT. Participants were randomized to twice-weekly, supervised, tailored exercise and fortnightly telephone-based nutrition education, for up to 8-weeks prior to autoSCT (n = 11) or usual care (n = 11). Blinded assessments occurred at baseline (T0), pre-transplant (T1), and 4-weeks post-transplant (T2). The primary outcome was physical capacity (6-min walk test). Secondary measures included recr

SUBMITTER: Dennett AM 

PROVIDER: S-EPMC11805779 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature