Unveiling the metabolomic profile of growth hormone deficiency children using NMR spectroscopy.

ABSTRACT:

Introduction

The diagnosis of Growth Hormone Deficiency (GHD) during childhood has been the subject of much controversy over the last few years. Aiming to accurate medical treatment, there is a need for biomarker discovery.

Objective

To characterize the metabolic profile of GHD children, examine the effect of GH administration on the metabolic signature, and investigate the correlations between metabolites and IGF-1.

Methods

Nuclear Magnetic Resonance (NMR)-based untargeted and targeted metabolomic approach applied to study the metabolic profiles of children with GHD. Plasma, serum, and urine samples were collected from twenty-two children diagnosed with GHD and forty-eight age matched controls from the Pediatric Endocrinology Unit of the University Hospital of Patras

SUBMITTER: Aggelaki EA 

PROVIDER: S-EPMC11805833 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature