Searching for the cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer's disease.

ABSTRACT: Neurodegenerative diseases such as Alzheimer's disease exhibit pathological changes in the brain that proceed in a stereotyped and regionally specific fashion. However, the cellular underpinnings of regional vulnerability are poorly understood, in part because whole-brain maps of a comprehensive collection of cell types have been inaccessible. Here, we deployed a recent cell-type mapping pipeline, Matrix Inversion and Subset Selection (MISS), to determine the brain-wide distributions of pan-hippocampal and neocortical cells in the mouse, and then used these maps to identify general principles of cell-type-based selective vulnerability in PS19 mouse models. We found that hippocampal glutamatergic neurons as a whole were significantly positively associated with regional tau deposition, sugge

SUBMITTER: Torok J 

PROVIDER: S-EPMC11806020 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature