A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula.

ABSTRACT: The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. In recent years, single-cell RNA sequencing studies have uncovered cellular diversity in the retina of a variety of species, providing new insights on retinal evolution and development. However, similar data in cartilaginous fishes, the sister group to all other extant jawed vertebrates, are still lacking. Here, we present a single-nucleus RNA sequencing atlas of the postnatal retina of the catshark Scyliorhinus canicula, consisting of the expression profiles for 17,438 individual cells from three female, juvenile catshark specimens. Unsupervised clustering revealed 22 distinct cell types comprising all major retinal cell classes, as w

SUBMITTER: Vidal-Vazquez N 

PROVIDER: S-EPMC11806052 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature