Causal associations between socioeconomic status and prostate cancer using two-sample Mendelian randomization study.

ABSTRACT: Prostate cancer (PCa) is a common form of malignancy among men. The associations between socioeconomic status (SES) indicators and PCa risks remain incompletely elucidated. Through two-sample Mendelian randomization (MR), this research seeks to assess the causal links between 4 genetically predicted SES indicators-average total household income before tax, the Townsend deprivation index at recruitment, unemployed status and college or university degree in the household-and PCa. Genetic variants were extracted from publicly available genome-wide association studies (GWAS) under stringent threshold as instrumental variables (IVs). We employed the inverse variance weighted (IVW), weighted median, weighted mode and MR-Egger to estimate the causal effect, with sensitivity analyses such as Cochr

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11806085 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature