Synthetic transmembrane DNA receptors enable engineered sensing and actuation.

ABSTRACT: In living organisms, cells synergistically couple cascade reaction pathways to achieve inter- and intracellular signal transduction by transmembrane protein receptors. The construction and assembly of synthetic receptor analogs that can mimic such biological processes is a central goal of synthetic biochemistry and bionanotechnology to endow receptors with user-defined signal transduction effects. However, designing artificial transmembrane receptors with the desired input, output, and performance parameters are challenging. Here we show that the dimerization of synthetic transmembrane DNA receptors executes a systematically engineered sensing and actuation cascade in response to external molecular signals. The synthetic DNA receptors are composed of three parts, including an extracellular

SUBMITTER: Zhou ZR 

PROVIDER: S-EPMC11806108 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature