Deciphering molecular crosstalk mechanisms between skeletal muscle atrophy and KRAS-mutant pancreatic cancer: a literature review.

ABSTRACT:

Background and objective

Cachexia-induced skeletal muscle atrophy is a critical manifestation in Kirsten rat sarcoma viral oncogene homologue (KRAS)-mutant pancreatic cancer (PC) patients, predominantly characterized by a shift in metabolic equilibrium towards catabolism that accelerates protein degradation in myofibers and leads to muscle atrophy. This metabolic reprogramming not only supports tumor growth but also precipitates energy depletion in skeletal muscle tissues. Exploring these mechanisms reveals potential therapeutic targets in the metabolic and proteolytic pathways associated with KRAS-mutant PC.

Methods

A comprehensive search for literature was conducted in PubMed, Web of Science, Google Scholar and other search engines up to May 21^st, 2024. Studies

SUBMITTER: Guo Y 

PROVIDER: S-EPMC11806137 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature