Plasma GLP-1 and metabolic dynamics during human liver regeneration and their association with posthepatectomy liver failure.

ABSTRACT:

Background

Metabolic regulation is critical during liver regeneration in rodents, but human data are limited. We investigated perioperative dynamics of circulating metabolites and plasma levels of glucagon-like peptide-1 (GLP-1) and GLP-2, in patients undergoing liver resections, exploring their associations with the histological phenotype of metabolic dysfunction-associated steatotic liver disease (MASLD) and posthepatectomy liver failure (PHLF).

Methods

Eighty-one and 75 patients from two centers between 2012 and 2023 were studied. Targeted quantitative metabolomic assay of 180 circulating metabolites, perioperative GLP-1, GLP-2, and standard lipid parameter level evaluation was employed. An exploratory PHLF prediction model was developed, including GLP-1 as a metabolic pa

SUBMITTER: Ammann M 

PROVIDER: S-EPMC11806138 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature