Effect of zinc on sperm recovered by swim-up.

ABSTRACT:

Purpose

Zinc is known to influence chromatin stability, motility and protection against oxidative stress. While swim-up remains the preferred method for selecting sperm in Assisted Reproductive Technologies (ART), concerns arise regarding sperm DNA fragmentation associated with this procedure. Given zinc's significant role in protecting sperm DNA integrity and motility, we aimed to investigate the impact of zinc supplementation during the swim-up process on sperm quality.

Methods

Semen samples from 203 normozoospermic men were used. Samples were divided into fractions and swim-up procedure was applied using human tubal fluid (mHTF) supplemented with three different concentrations of zinc or medium without supplementation as control. DNA fragmentation, chromatin maturity, rea

SUBMITTER: Faggi M 

PROVIDER: S-EPMC11806184 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature